Īzuma J, Sawamura A, Awata N, Ohta H, Hamaguchi T, Harada H, Takihara K et al (1985) Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial. This article examines the mechanism underlying the effects of taurine on age-related changes, which may have potential clinical implications.Īnderson R, Prolla T (2009) PGC-1alpha in aging and anti-aging interventions. Upon intestinal absorption, taurine might modulate age-related changes in respiratory metabolism and skeletal muscle function via peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), succinate dehydrogenase (SDH), cytochrome c (Cycs), myocyte enhancer factor 2A (MEF2A), glucose transporter 4 (GLUT4), and myoglobin, which are regulated by the activation of AMP-activated protein kinase (AMPK). Our findings suggest that long-term administration of taurine at relatively low dose could attenuate the age-related decline in O 2 consumption and spontaneous locomotor activity. SD rats were stabilized for 32–34 weeks and divided into three groups, administrated water (control), 0.5% taurine (25 mg/kg body weight (BW)/day), or 1% taurine (50 mg/kg BW/day) from age 34 to 56 weeks (5 days/week, 5 mL/kg BW). In Experiment 2, we examined the effects of long-term (21-week) administration of taurine on healthy aging SD rats. In Experiment 1, we examined age-related changes in aging Sprague–Dawley (SD) rats (32–92 weeks old) that O 2 consumption and spontaneous activity decreased significantly with aging. In this study, we investigated the effects of long-term administration of taurine at low doses on aging in rodents. Most energy drinks contain this amino acid however, there is insufficient research on the effects of long-term, low-dose supplementation of taurine. Increasing evidence suggests that taurine plays a role in the maintenance of skeletal muscle function and increase of exercise capacity. Taurine (2-aminoethanesulfonic acid) is a free amino acid found abundantly in mammalian tissues.
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